| 主权项 |
1. A method of selectively depleting pathogenic T lymphocytes from a blood cell composition, comprising:
(a) combining said cell composition ex vivo with an active compound in an effective amount, and then (b) irradiating said cells with light ex vivo for a time and at an intensity sufficient to selectively kill pathogenic T lymphocytes in said cell composition; wherein said active compound is selected from the group consisting of: (i) compounds of Formula I:wherein:
E is S or Se; Ar is aryl or heteroaryl, each of which is substituted or unsubstituted; W, X, Y, and Z are each independently H or C1 through C8, linear or branched, alkyl; R1′, R2′, R1″ and R2″ are each independently H or C1 through C8, linear or branched, alkyl; and/or R1′ and R2′ are alkyl groups connected such that they together comprises a 3, 4, 5, 6 or 7-membered ring, which ring optionally bears alkyl or aryl substituents; and/or R1″ and R2″ are alkyl groups connected such that they together comprises a 3, 4, 5, 6 or 7-membered ring, which ring optionally bears alkyl or aryl substituents; and/or R1′ and Y are connected such that they together comprises a 5, 6 or 7-membered ring; and/or R1′ and Y are connected such that they together comprises a 5, 6 or 7-membered ring; and/or R2′ and Z are connected such that they together comprises a 5, 6 or 7-membered ring; and/or R1″ and W are connected such that they together comprises a 5, 6 or 7-membered ring; and/or R2″ and X are connected such that they together comprises a 5, 6 or 7-membered ring; and A is an anion; (ii) compounds of Formula Ia:wherein:
E is S or Se; E′ is O, S, NH, or NRe wherein Re is C1 to C6, linear or branched, alkyl; X′ is O or S; W, X, Y, and Z, and R1′, R2′, R1″ and R2″, are as described in connection with Formula I above; and Rc and Rd are each independently H or C1 to C6, linear or branched, alkyl, or Rc and Rd together form with N a 3, 4, 5 6, or 7 membered ring; and A is an anion; (iii) compounds of Formula Ib:wherein:
E is S or Se; X′ is O or S; W, X, Y, and Z, and R1′, R2′, R1″ and R2″, and Rc and Rd, are as described in connection with Formula I above; the group —C(═X′)(—NRcRd) can be in the 2—(ortho), 3—(meta), or 4—(para) position; and A is an anion; (iv) compounds of Formula IIa:wherein:
E is S or Se; E′ is O, S, NH, or NRe, wherein Re is C1 to C6, linear or branched, alkyl; X′ is O or S; W and X, R1″ and R2″, and Rc and Rd, are as described in connection with Formula I above; and A is an anion; (v) compounds of Formula IIb:wherein:
E is S or Se; X′ is O or S; W and X, R1″ and R2″, and Rc and Rd, are as described in connection with Formula I above; the group —C(═X′)(—NRcRd) can be in the 2—(ortho), 3—(meta), or 4—(para) position; and A is an anion; (vi) compounds of Formula IIIa:wherein:
E is S or Se; E′ is O, S, NH, or NRe, wherein Re is C1 to C6, linear or branched, alkyl; X′ is O or S; W and X, R1″ and R2″, and Rc and Rd, are as described in connection with Formula I above; and A is an anion; (vii) compounds of Formula IIIb:wherein:
E is S or Se; X′ is O or S; W and X, R1″ and R2″, and Rc and Rd, are as described in connection with Formula I above; the group —C(═X′)(—NRcRd) can be in the 2—(ortho), 3—(meta), or 4—(para) position; and A is an anion; (viii) compounds of Formula IVa:wherein:
E is S or Se; E′ is O, S, NH, or NRe, wherein Re is C1 to C6, linear or branched, alkyl; X′ is O or S; W and X, R1″ and R2″, and Rc and Rd, are as described in connection with Formula I above; and A is an anion; (ix) compounds of Formula IVb:wherein:
E is S or Se; X′ is O or S; W and X, R1″ and R2″, and Rc and Rd, are as described in connection with Formula I above; the group —C(═X′)(—NRcRd) can be in the 2—(ortho), 3—(meta), or 4—(para) position; and A is an anion; (x) compounds of Formula Va:wherein:
E is S or Se; E′ is O, S, NH, or NRe, wherein Re is C1 to C6, linear or branched, alkyl; X′ is O or S; Rc and Rd are as described in connection with Formula I above; and A is an anion; (xi) compounds of Formula Vb:wherein:
E is S or Se; X′ is O or S; Rc and Rd are as described in connection with Formula I above; the group —C(═X′)(—NRcRd) can be in the 2—(ortho), 3—(meta), or 4—(para) position; and A is an anion; (xii) compounds of Formula VIa:wherein:
E is S or Se; E′ is O, S, NH, or NRe, wherein Re is C1 to C6, linear or branched, alkyl; X′ is O or S; Rc and Rd are as described in connection with Formula I above; and each R′ is independently H or C1 to C6, linear or branched, alkyl; and A is an anion; (xiii) compounds of Formula VIb:wherein:
E is S or Se; X′ is O or S; Rc and Rd are as described in connection with Formula I above; each R′ is independently H or alkyl; the group —C(═X′)(—NRcRd) can be in the 2—(ortho), 3—(meta), or 4—(para) position; and A is an anion; (xiv) compounds of Formula VIIa:wherein:
E is S or Se; E′ is O, S, NH, or NRe, wherein Re is C1 to C6, linear or branched, alkyl; X′ is O or S; and each R′ is independently H or alkyl; each R″ is independently H or alkyl; Rc and Rd are as described in connection with Formula I above; and A is an anion; and (xv) compounds of Formula VIIb:wherein:
E is S or Se; X′ is O or S; each R′ is independently H or alkyl; each R″ is independently H or alkyl; Rc and Rd are as described in connection with Formula I above; and the group —C(═X′)(—NRcRd) can be in the 2—(ortho), 3—(meta), or 4—(para) position; and A is an anion. |
