| 发明名称 |
SURFACTANT-FREE HIV PROTEASE INHIBITOR COMPOSITION AND METHOD OF MANUFACTURING THEREOF |
| 摘要 |
Disclosed are pharmaceutical compositions, e.g., in the form of tablets, containing a therapeutically effective amount of an HIV protease inhibitor, e.g., ritonavir, a pharmaceutically acceptable aqueous-soluble polymer, and an erosion-enhancing agent having a particle size distribution in the range of about 1 μm to about 350 μm, wherein the composition is substantially free or free of surfactant. Methods of making the compositions, and methods of using them to treat HIV infection are also provided. |
| 申请公布号 |
US2017071915(A1) |
申请公布日期 |
2017.03.16 |
| 申请号 |
US201615001960 |
申请日期 |
2016.01.20 |
| 申请人 |
KASHIV PHARMA, LLC |
发明人 |
SHAH NAVNIT H.;THONGSUKMAK ATSAWIN;VAGHASHIYA JAYDEEP;DESAI DIPEN;PHUAPRADIT WANTANEE |
| 分类号 |
A61K31/427;A61K47/02;A61K9/20;A61K47/32 |
主分类号 |
A61K31/427 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising a therapeutically effective amount of amorphous ritonavir, a pharmaceutically acceptable aqueous-soluble polymer, and an erosion-enhancing agent having a particle size distribution in the range of about 1 μm to about 350 μm, wherein the composition is free of surfactant. |
| 地址 |
BRIDGEWATER NJ US |
