| 摘要 |
The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as aminotransferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease. |
| 主权项 |
1. A method for the treatment of a liver disease selected from an alcohol-related liver disease, a viral liver disease and an immune-mediated liver disease in a subject in need thereof, comprising administering to the subject a compound of General Formula (I) in which: X1 is a halogen, a R1, or G1-R1 group; A is a CH═CH or a CH2-CH2 group; X2 is a G2-R2 group; G1 and G2, identical or different, are an atom of oxygen or sulfur; R1 is a hydrogen atom, an unsubstituted alkyl group, an aryl group or an alkyl group that is substituted by one or more halogen atoms, an alkoxy or an alkylthio group, cycloalkyl groups, cycloalkylthio groups or heterocyclic groups; R2 is an alkyl group substituted by at least a —COOR3 group, wherein R3 is a hydrogen atom, or an alkyl group that is substituted or not by one or more halogen atoms, cycloalkyl groups, or heterocyclic groups; R4 and R5, identical or different, corresponding to an alkyl group that is substituted or not by one or more halogen atoms, cycloalkyl groups, heterocyclic groups; or a pharmaceutically acceptable salt or a stereoisomer thereof. |
