| 发明名称 |
ANTI-PSYK ANTIBODY MOLECULES AND USE OF SAME FOR SYK-TARGETED THERAPY |
| 摘要 |
The invention relates to antibody molecules which bind pSYK, and methods for using the same for diagnosis, prognosis, to select patients for treatment with a SYK-targeted therapy, or evaluate the pharmacodynamic profile of a SYK-targeted therapy. |
| 申请公布号 |
US2017037151(A1) |
申请公布日期 |
2017.02.09 |
| 申请号 |
US201515305340 |
申请日期 |
2015.04.21 |
| 申请人 |
Millennium Pharmaceuticals, Inc. |
发明人 |
BRAKE Rachael L.;BURKHARDT Anne L.;HE MCDOUGALL Helen D.;KANNAN Karuppiah;THEISEN Matthew;TIRRELL Stephen M. |
| 分类号 |
C07K16/40;G01N33/573;G01N33/574;A61K31/437 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An anti-pSYK antibody molecule comprising three heavy chain complementarity determining regions (CDR1, CDR2, and CDR3) comprising amino acid sequences SEQ ID NOs: 11, 12 and 13, respectively; and three light chain complementarity determining regions (CDR1, CDR2, and CDR3) comprising amino acid sequences SEQ ID NOs:14, 15 and 16, respectively. |
| 地址 |
Cambridge MA US |
