Antifouling heparin coatings

摘要

A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

主权项

1. A medical device comprising a substrate and a polymeric coating which comprises a biocompatible polymer and heparin,
wherein heparin is attached to the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein, wherein the spacer is of a formula of Y-R-X where X and Y represent two functional groups and R represents a monomeric di-radical; wherein X and Y groups are independently selected from the group consisting of hydroxyl, epoxide, carboxyl, amino, imide, aziridine, thiol, phosphoryl, aldehyde, anhydride, acyl halide, silyl, isocyanate, di-isocyanate, carbodiimide, a dihydrazide, a multiaziridine, a multifunctional carbodiimide, a diamine, N-hydroxy-succinamide, acryloxy terminated polyethylene, glycol, methacryloxy terminated polyethylene glycol, and isothiocyanate; and R is a dextrose di-radical; and wherein heparin is molecular heparin, a fragment of heparin, or a derivative thereof.