Intravenous administration of tramadol

摘要

A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously over a prolonged time period is disclosed. In certain embodiments, the dose is intravenously administered in a time period from about 10 minutes to about 3 hours, preferably from about 10 minutes to about 30 minutes. In other embodiments, intravenous doses are administered at suitable time intervals over a time period from about 3 hours to 48 hours.

主权项

1. A method of treating moderate to severe acute pain, comprising administering to a human patient a dose of about 50 mg of tramadol intravenously over a time period from 10 minutes to 20 minutes, and administering further doses of tramadol at from about 2 to about 6 hour time intervals to treat pain in said patient, wherein each dose of tramadol is administered intravenously over a time period from 10 minutes to 20 minutes, such that the human patient is treated for moderate to severe acute pain and such that the Cmax does not exceed the Cmax of 100 mg oral tramadol administered every 6 hours for 9 doses.