PERIPHERAL NEUROPATHY DIAGNOSIS

摘要

Genes whose expression is correlated with the presence of CIDP or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject.

主权项

1. A method for detecting whether a human subject is likely to have chronic inflammatory demyelinating polyneuropathy (CIDP) or vasculitic neuropathy,
comprising determining in a sample from the subject, which is processed from a biopsy of a peripheral nerve or a tissue that contains peripheral nerve fibers, the expression level, compared to a baseline value, of macrophage scavenger receptor 1 (MSR1), wherein the baseline value is indicative of the average level of expression of MSR1 in the same type of sample of a pool of subjects that have normal appearing nerves polyneuropathy, and wherein a significant degree of over-expression of MSR1 indicates that the subject is likely to have CIDP or vasculitic neuropathy.