| 发明名称 |
NOTCH3 ANTIBODIES AND USES THEREOF |
| 摘要 |
Novel antibodies that specifically bind human NOTCH3 are provided. Methods and kits using these antibodies to determine the level of NOTCH3 expression in tumor samples are provided. |
| 申请公布号 |
US2017023576(A1) |
申请公布日期 |
2017.01.26 |
| 申请号 |
US201515301161 |
申请日期 |
2015.04.03 |
| 申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
CANCILLA Belinda |
| 分类号 |
G01N33/574;C07K16/32;G01N33/58;A61K31/7068;C07K16/30;C07K16/28;A61K39/395 |
主分类号 |
G01N33/574 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody that specifically binds the extracellular domain of human NOTCH3, which comprises:
(a) a heavy chain CDR1 comprising TKYTIH (SEQ ID NO:39), a heavy chain CDR2 comprising YINPSNDYTNYNQTFKD (SEQ ID NO:40), and a heavy chain CDR3 comprising ARGTTPYSLDY (SEQ ID NO:41); and (b) a light chain CDR1 comprising RASESVDNYGMSFMN (SEQ ID NO:42), a light chain CDR2 comprising AASNQGS (SEQ ID NO:43), and a light chain CDR3 comprising LQSKEVP (SEQ ID NO:44). |
| 地址 |
Redwood City CA US |
