发明名称 |
M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications |
摘要 |
Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding. |
申请公布号 |
US9551666(B2) |
申请公布日期 |
2017.01.24 |
申请号 |
US201313800526 |
申请日期 |
2013.03.13 |
申请人 |
University of South Carolina |
发明人 |
Wang Qian;Li Kai;Mello Charlene |
分类号 |
C12Q1/70;G01N21/64;C12N7/00 |
主分类号 |
C12Q1/70 |
代理机构 |
Dority & Manning, P.A. |
代理人 |
Dority & Manning, P.A. |
主权项 |
1. A dual-modified M13 bacteriophage comprising
a M13 bacteriophage; a cancer-targeting substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage and a benzene diazonium linkage; and a fluorescent group covalently attached to the M13 bacteriophage. |
地址 |
Columbia SC US |