COMPOSITIONS AND METHODS FOR DETECTION OF GENETIC DEAFNESS GENE MUTATION

摘要

In one aspect, a kit for detection of genetic gene mutation is provided, which is used for detecting nine deafness gene mutations of Caucasian populations, including GJB2 (c. 35delG, c. 167delT, c. 132G>C, and c. 269T>C), GJB6 (c. del309kb), SLC26A4 (c. 707T>C and c. 1246A>C), 12S rRNA (m. 1555A>G and m. 7444G>A). In another aspect, a method is provided, which method comprises labeling a target molecule with a luminophore, coupling the target molecule to a particle, and binding to a probe molecule on microarray. In some aspects, this technology, with high sensitivity, enables the detection and interpretation of molecular interactions in an efficient way.