METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE

摘要

The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation product. Measuring the quantity of one or more HDL oxidation products present in the blood is useful in evaluating risk for developing or evaluating the se verity of a disease or evaluating response to treatment for such a disease as, for instance, cardiovascular disease

主权项

1. A system comprising:
a) isotope-labeled 3-chlorotyrosine and/or isotope-labeled 3-nitrotyrosine; b) a gas chromatograph and/or a mass spectrometer; and c) a treated sample from a subject having, or at risk for, cardiovascular disease, wherein said treated sample: i) comprises isolated HDL, and ii) is depleted in ApoB and ApoE proteins.