发明名称 |
A MICROFLUIDIC DEVICE FOR REAL-TIME CLINICAL MONITORING AND QUANTITATIVE ASSESSMENT OF WHOLE BLOOD COAGULATION |
摘要 |
In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate. |
申请公布号 |
EP3058367(A4) |
申请公布日期 |
2017.01.11 |
申请号 |
EP20140877132 |
申请日期 |
2014.10.16 |
申请人 |
President and Fellows of Harvard College |
发明人 |
JAIN, Abhishek;WATERHOUSE, Anna;SUPER, Mike;INGBER, Donald E.;LESLIE, Daniel C. |
分类号 |
G01N33/49;G01N33/86 |
主分类号 |
G01N33/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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