发明名称 Methods for treating and/or reversing neurodegenerative diseases and/or disorders
摘要 The present disclosure provides methods for the treatment of neurological diseases/disorders using neural stem cells (NSCs) obtained from a spinal cord tissue. The methods may include the use of a NSC population to treat a neurological disease/disorder of the brain. Such methods may include introducing exogenously cultured and expanded NSCs into the brain, which differentiate into neurons capable of integrating in vivo into the brain tissue in a sufficient manner to ameliorate the symptoms associated with the neurological disease/disorder.
申请公布号 US9540611(B2) 申请公布日期 2017.01.10
申请号 US201113192972 申请日期 2011.07.28
申请人 Neuralstem, Inc. 发明人 Shyu Woei-Cherng;Lin Shinn-Zong;Wang Hsiao-Jung;Johe Karl K.
分类号 C12N5/0797;C12N5/074;A01N63/00;A61K35/30 主分类号 C12N5/0797
代理机构 Morgan, Lewis & Bockius LLP 代理人 Morgan, Lewis & Bockius LLP ;Betti Christopher J.
主权项 1. A method for inhibiting or relieving a disease or disorder associated with neuronal cell loss in a brain, said method comprising: a) obtaining at least one stem cell from spinal cord tissue of a human having a gestational age of about 5 to about 20 weeks; b) expanding the at least one stem cell to form an expanded stem cell population; and c) injecting a therapeutically effective amount of the expanded stem cell population to at least one area of the brain of a subject.
地址 Germantown MD US