1-substituted, 4-(substituted phenoxymethyl)-1,2,3-triazole compounds with antifungal properties and methods for preparation thereof

摘要

Disclosed herein are novel antifungal compounds of Formula 1, containing 1-substituted, 4-(substituted phenoxy-methyl)-1,2,3-triazole moieties coupled to a core having triazole ring, (un)substituted phenyl ring and tertiary alcoholic functionality, and pharmaceutically acceptable salts thereof; methods for preparing these compounds; and pharmaceutical preparations containing these novel compounds for prevention and treatment of fungal infections.;

主权项

1. An antifungal compound of Formula 1, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently selected from the group consisting or hydrogen and a halogen; R3 is selected from the group consisting of hydrogen, a halogen, a substituted or unsubstituted alkyl having a linear or branched chain of 1 to 20 carbon atoms, a substituted or unsubstituted aryl, nitro, a substituted or unsubstituted alkylamino, a substituted or unsubstituted arylamino, a substituted or unsubstituted heteroarylamino, C(O)R4, —COCH═CHR5, —CH═CH—COR6, or a substituted or unsubstituted alkenyl; R4 is selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl having a linear or branched chain of 1 to 20 carbon atoms, and a substituted or unsubstituted alkenyl having a linear or branched chain of 1 to 20 carbon, atoms; and R5 selected from the group consisting of a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl, and a substituted or unsubstituted heteroaryl.