发明名称 |
ANTIBACTERIAL AGENTS: N(ALPHA)-AROYL-N-ARYL-PHENYLALANINAMIDES |
摘要 |
The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment or prevention of M. tuberculosis infections in a mammal, is disclosed. |
申请公布号 |
US2016347708(A1) |
申请公布日期 |
2016.12.01 |
申请号 |
US201515116787 |
申请日期 |
2015.02.06 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY |
发明人 |
Ebright Richard H.;Ebright Yon W.;Mandal Soma;Wilde Richard;Li Shengjian |
分类号 |
C07C233/88;A01N37/24;C07D295/135;A01N43/84;C07D295/155;A01N43/36;C07D249/08;A01N43/653;C07D249/06;A01N43/647;C07D257/04;A01N43/713;C07D213/75;A01N43/40;C07D213/81;C07D209/08;A01N43/38;C07D333/54;A01N43/10;A01N43/48;A01N37/22 |
主分类号 |
C07C233/88 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
New Brunswick NJ US |