| 摘要 |
The purpose of the present invention is to provide: an HTLV-I-specific CD4+ T cell-induction activity peptide that has an activity of inducing a CD4+ T cell being specific to HTLV-I; an HTLV-I-specific CTL-induction effect enhancer that comprises the aforesaid peptide; and a vaccine for inducing an HTLV-I-specific immunity response, a diagnostic for examining an immune function, etc. each using the same. In the present invention, an HTLV-I-specific CD4+ T cell-induction activity peptide, which comprises an amino acid sequence of any of (A) to (E), etc. are used: (A) an amino acid sequence represented by any of SEQ ID NOS: 4, 10, 11, 12, 13, 16, 17 and 19; (B) an amino acid sequence consisting of 14 to 30 consecutive amino acids in the amino acid sequence represented by SEQ ID NO:32, said amino acid sequence including the amino acid sequence of at least amino acid nos. 155 to 167; (C) an amino acid sequence having a homogeneity of 80% or greater with the amino acid sequence of (A) or (B), a peptide comprising said amino acid sequence having an HTLV-I-specific CD4+ T cell-induction activity; (D) an amino acid sequence derived from the amino acid sequence of (A) or (B) by deletion, substitution or addition of one to several amino acids, a peptide comprising said amino acid sequence having an HTLV-I-specific CD4+ T cell-induction activity; and (E) an amino acid sequence comprising an amino acid sequence consisting of 14 to 30 consecutive amino acids in the amino acid sequence represented by SEQ ID NO:32, said amino acid sequence including the amino acid sequence of at least amino acid nos. 155 to 167 together with the amino acid sequence of an HTLV-I-specific CTL-induction activity peptide bonded thereto. |
