摘要 |
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BROCKUNIER, LINDA L.;CHEN, HELEN;CHOBANIAN, HARRY R.;CLEMENTS, MATTHEW J.;CRESPO, ALEJANDRO;DEMONG, DUANE E.;GUO, YAN;HAGMANN, WILLIAM K.;MARCANTONIO, KAREN M.;MILLER, MICHAEL;PIO, BARBARA;PLUMMER, CHRISTOPHER W.;XIAO, DONG |