There is disclosed a Dolastatin derivative, conjugated to an antibody, comprising a Dolastatin derivative moiety of Formula IV. The disclosure provides compounds and conjugates, such as ADC (antibody drug conjugates), wherein a linker moiety that is peptide based has an attaching point at its C-terminal which reacts with either Cys or Lys on an antibody in a controlled fashion.
申请公布号
WO2016123412(A1)
申请公布日期
2016.08.04
申请号
WO2016US15482
申请日期
2016.01.28
申请人
SORRENTO THERAPEUTICS, INC.
发明人
MIAO, ZHENWEI;CHEN, GANG;ZHU, TONG;KHASANOV, ALIDHER, B.;DENG, DYLAN;ZHANG, HONG