发明名称 |
MODIFIED ANTI-INFLAMMATORY PROTEINS AND METHOD OF USE |
摘要 |
A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease. |
申请公布号 |
EP3046937(A1) |
申请公布日期 |
2016.07.27 |
申请号 |
EP20140845452 |
申请日期 |
2014.09.18 |
申请人 |
JAMES COOK UNIVERSITY |
发明人 |
LOUKAS, ALEX;PICKERING, DARREN;LEECH, ANDREW |
分类号 |
C07K14/81;A61K38/57;A61P11/00;A61P29/00;A61P37/00;C12N15/15;C12N15/63 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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