Systems and Methods for Improved Delivery of Osteoinductive Molecules in Bone Repair

摘要

Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

主权项

1. A composition, comprising:
a preformed calcium ceramic granule having a specific surface area greater than 30 m2/g and having an interconnected network of micropores defining at least one surface on an interior of the granule; and an osteoinductive protein associated with the at least one interior surface wherein the osteoinductive protein is distributed on a portion of the interior surface near the centroid of the granule and on an interior surface near the exterior of the granule.