发明名称 |
LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS |
摘要 |
The invention provides for double stranded nucleic acid molecules comprising a 5 'extension of the sense or antisense strand and further comprising a plurality of nucleotides that are conjugated to a ligand and methods of using the double-stranded nucleic acid molecules. Ligand-modified oligomers where the sense stands form a tetraloop provide new potent and stable RNA interference agents. These dsNA molecules are synthesized using a plurality of nucleotides that include ligand-modified monomers, nucleotide analog monomers, modified nucleotide monomers and the like, using standard nucleotide synthetic methods and systems. |
申请公布号 |
WO2016100401(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
WO2015US65906 |
申请日期 |
2015.12.15 |
申请人 |
DICERNA PHARMACEUTICALS, INC. |
发明人 |
BROWN, BOB, DALE;WANG, WEIMIN |
分类号 |
C12N15/11;C12N15/113 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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