| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:
Ar is aryl or heteroaryl, wherein each aryl or heteroaryl is optionally substituted with one or more halogens or C1-C6 alkyl;n is 1, 2, 3 or 4;X is CH2, CH, S, O or C2-C6 alkynyl;Y is C1-C3 alkyl, C2-C6 alkynyl or interarylene, wherein C1-C3 alkyl is optionally substituted by OH;Z is interarylene, C1-C3 alkyl, CH2S, CH2O or a bond;Q is H, halogen, CF3, OCF3, CO2R2, CH2OR2, CONR2R3 or tetrazol-5-yl;A is H, halogen, C1-C10 alkyl, C1-C10 alkyl branched alkyl, or CO2R3, wherein each C1-C10 alkyl, or C1-C10 alkyl branched alkyl contains one or more groups selected from the groups consisting of OH, OR and NR2;B is H, halogen, C1-C10 alkyl, or C1-C10 alkyl branched alkyl, wherein each C1-C10 alkyl, or C1-C10 alkyl branched alkyl contains one or more groups selected from the groups consisting of OH, OR and NR2;R is H or C1-C6 alkyl;R1 is H, C1-C6 alkyl, CF3, phenyl or biphenyl;R2 is H, C1-C6 alkyl, C(O)R1 or SO2R1; andR3 is H or C1-C6 alkyl. |
