Diagnostic agent for tumor

摘要

According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising δ-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof:
R2R1NCH2COCH2CH2COR3  (I)
wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.

主权项

1. A method for detecting the presence of tumors which comprises orally administering to a subject in need of said detecting δ-aminolevulinic acid represented by formula (I):
R2R1NCH2COCH2CH2COR3  (I) wherein R1 and R2 each independently represents hydrogen and R3 represents hydroxy or alkoxy or a salt thereof, collecting a sample from said subject and then measuring the concentration of porphyrins in the sample to thereby detect the presence of said tumors, wherein the sample is collected from the inside or outside of the body and is blood, body fluid, urine, feces, saliva, sweat, cerebrospinal fluid, semen or tears, wherein the porphryins are uroporphyrin, coproporphryin, uroporphyrin I, uroporphyrin III, coproporphyrin I, or coproporphyrin III, and wherein the sample is collected from the inside or outside of the body after from 0.1 to 10 hours of the administration of the δ-aminolevulinic acid or salt thereof.