发明名称 |
METHOD FOR EVALUATING MITOCHONDRIAL MEMBRANE PERMEABILITY, METHOD FOR SCREENING SUBSTANCE THAT INHIBITS PROMOTION OF MITOCHONDRIAL MEMBRANE PERMEABILITY, METHOD FOR SCREENING SUBSTANCE THAT PROMOTES MITOCHONDRIAL MEMBRANE PERMEABILITY, AND MITOCHONDRIAL MEMBRANE PERMEABILITY PROMOTION INHIBITOR |
摘要 |
PROBLEM TO BE SOLVED: To provide a method for evaluating mitochondrial membrane permeability, the method being able to evaluate the first stage of cell death.SOLUTION: The method for evaluating mitochondrial membrane permeability comprises the steps of adding an indicator of calcium ion (Ca) to a reaction liquid containing a cell to be examined in vitro, measuring a calcium ion amount using the indicator of calcium ion as an index, and comparing the measured calcium ion amount with a first reference value, wherein when the measured calcium ion amount exceeds the first reference value, it is evaluated that the mitochondrial membrane permeability of the cell to be examined has been promoted.SELECTED DRAWING: None |
申请公布号 |
JP2016073209(A) |
申请公布日期 |
2016.05.12 |
申请号 |
JP20140204141 |
申请日期 |
2014.10.02 |
申请人 |
HEALTHCARE SYSTEMS CO LTD;HAMAMATSU PHOTONICS KK |
发明人 |
NAOI MAKOTO;WU YUCHU;OSAWA TOSHIHIKO;SHIKIMURA KIMIKO |
分类号 |
C12Q1/02;A61K31/36;A61P43/00 |
主分类号 |
C12Q1/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|