Methods of treating neuronal inflammation using an IL-31 monoclonal antibody

摘要

Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.

主权项

1. A method of treating neuronal tissue inflammation in a mammal comprising administering to the mammal a humanized monoclonal antibody derived from the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815, wherein the humanized monoclonal antibody comprises a human IgG4 heavy chain immunoglobulin constant domain, and wherein after administration the mammal's neuronal tissue inflammation is reduced.