Leukemia stem cell targeting ligands and methods of use

摘要

The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (LSCs) and targeted therapy against leukemia mediated at least in part by CLL1-expressing LSCs.

主权项

1. A peptide comprising the amino acid sequence motif LR(S/T), wherein the peptide is no longer than 10 amino acids in length and binds to C-type lectin-like molecule-1 (CLL1), wherein the peptide comprises the amino acid sequence X1LRX4X5X6X7 (SEQ ID NO: 1), wherein:
X1 is D, T or V; X4 is S or T; X5 is A, S or F; X6 is A, G or S; and X7 is A, V, P or F, and wherein the peptide binds to C type lectin-like molecule-1 (CLL1) expressed on the surface of leukemia stem cells and does not bind to normal blood cells or normal hematopoietic stem cells.