Method of detecting phosphorylation state of beta-catenin

摘要

The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.

主权项

1. A method of detecting a phosphorylation state of β-catenin comprising determining whether Serine552 of β-catenin is phosphorylated, wherein the determining step comprises contacting 13-catenin with an antibody that binds specifically to β-catenin phosphorylated at amino acid position Serine552, and wherein the antibody is an antibody deposited with the ATCC under accession number PTA-9077.