Compounds for improving nutritional status, cognition and survival

摘要

The present invention concerns using a leptin protein, a variant fragment or mimic of a leptin protein, or an activator of the AMPK signal transduction pathway for preparing a medicament that can either be used to improve cognitive function or to treat treatment of undesirable manifestations of a nutritional stress condition and to prolong survival.

主权项

1. A method for treating undesirable manifestations of a nutritional stress condition selected from the group consisting of sepsis, prolonged post-surgical stress, prolonged post injury stress, brain damage caused by liver disease; and weight loss associated with severe malnutrition, a mal-absorption condition that can lead to chronic malnutrition, malnutrition caused by cancer or infection, or anorexia, comprising:
administering to a subject having said nutritional stress condition a therapeutically effective amount of one or more agents selected from the group consisting of:
a leptin protein, a fragment of a leptin protein having physiological properties of the leptin protein, variant leptin protein or variant of a fragment of a leptin protein fragment having physiological properties of the leptin protein,a leptin receptor agonist being a leptin mimic, andan activator of the AMPK signal transduction pathway, wherein the subject is other than one having Alzheimer's Disease.