Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability

摘要

Provided herein are methods for decreasing blood-brain barrier permeability in a subject with neuroinflammatory disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its high affinity Plexin-B1 receptor.