Lipid delivery formulations

摘要

The invention provides formulations that contain an immunogenic or immunostimulatory cargo, delivery moiety and/or lipid, and a lipid that functions to reduce or prevent induction in a subject of an immune response which would otherwise occur when the immunogenic or immunostimulatory cargo, delivery moiety and/or lipid is administered to a subject as a component of an appropriate control formulation lacking the immune response reducing lipid. Specific immune response reducing lipids and uses thereof are further provided.

主权项

1. A formulation comprising:
an agent that induces an immune response when administered to a mammalian subject; and a first lipid that reduces said immune response to said agent in a mammalian subject, as compared to an immune response to a control formulation comprising said agent but lacking said first lipid; and wherein said first lipid is selected from the group consisting of: DPC-036, DPC-4, DPC-1, DPC-2, DPC-3, DPC-12, DPC-8, DPC-7, DPC-6, DPC-5, DPC-9, DPC-10, DPC-11 and DPC-13.