| 主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein:
A is selected from —CH2CH2—; wherein:
denotes the point of attachment to the carbonyl group and denotes the point of attachment to the nitrogen atom;n is 0, 1, or 2;m is 1 or 2;m′ is 0 or 1;z is 1 or 2;when z is 1, w is 2;when z is 2, w is 1 or 2;p is 0, 1, or 2;R14 and R15 are independently selected from hydrogen and methyl;Rx is selected from hydrogen, amino, hydroxy, and methyl; andRz is selected from hydrogen and —C(O)NHR16; wherein R16 is selected from hydrogen, —CHR17C(O)NH2, —CHR17C(O)NHCHR18C(O)NH2, and —CHR17C(O)NHCHR18C(O)NHCH2C(O)NH2; wherein R17 is selected from hydrogen and —CH2OH and wherein R18 is selected from hydrogen and methyl;Rv is hydrogen, methyl, or a natural amino acid side chain;Rc, Rf, Rh, Ri, and Rm are hydrogen;Rn is hydrogen or methyl or Rv and Rn form a pyrrolidine ring;Ra, Re, Rj, and Rk, are each independently selected from hydrogen and methyl;R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are independently selected from a natural amino acid side chain and an unnatural amino acid side chain or form a ring with the corresponding vicinal R group as described below;Re and Rk can each form a ring with the corresponding vicinal R group and the atoms to which they are attached selected from azetidine, pyrollidine, morpholine, piperidine, piperazine, and tetrahydrothiazole; wherein each ring is optionally substituted with one to four groups independently selected from amino, cyano, methyl, halo, and hydroxy;Rb is methyl or, Rb and R2, together with the atoms to which they are attached, form a ring selected from azetidine, pyrollidine, morpholine, piperidine, piperazine, and tetrahydrothiazole; wherein each ring is optionally substituted with one to four groups independently selected from amino, cyano, methyl, halo, and hydroxy;Rd is hydrogen or methyl, or, Rd and R4, together with the atoms to which they are attached, can form a ring selected from azetidine, pyrollidine, morpholine, piperidine, piperazine, and tetrahydrothiazole; wherein each ring is optionally substituted with one to four groups independently selected from amino, cyano, methyl, halo, hydroxy, and phenyl;Rg is hydrogen or methyl or Rg and R7, together with the atoms to which they are attached, can form a ring selected from azetidine, pyrollidine, morpholine, piperidine, piperazine, and tetrahydrothiazole; wherein each ring is optionally substituted with one to four groups independently selected from amino, benzyl optionally substituted with a halo group, benzyloxy, cyano, cyclohexyl, methyl, halo, hydroxy, isoquinolinyloxy optionally substituted with a methoxy group, quinolinyloxy optionally substituted with a halo group, and tetrazolyl; and wherein the pyrrolidine and the piperidine ring are optionally fused to a cyclohexyl, phenyl, or indole group; andRL is methyl or, RL and R12, together with the atoms to which they are attached, form a ring selected from azetidine and pyrollidine, wherein each ring is optionally substituted with one to four groups independently selected from amino, cyano, methyl, halo, and hydroxy. |
