METHODS OF INCREASING NEURONAL DIFFERENTIATION USING ANTIBODIES TO LYSOPHOSPHATIDIC ACID

摘要

PROBLEM TO BE SOLVED: To provide methods for increasing neuronal differentiation of neuronal stem cells using antibodies that bind lysophosphatidic acid (LPA).SOLUTION: Preferred antibodies to LPA are monoclonal antibodies, including humanized monoclonal antibodies to LPA. In the methods, the antibodies, and derivatives and variants thereof, are used in increasing neuronal differentiation, and in treatment and/or prevention of injuries, diseases, or conditions associated with insufficient neuronal differentiation and/or with elevated LPA levels in neural tissues.SELECTED DRAWING: None