发明名称 |
A LAGLIDADG HOMING ENDONUCLEASE CLEAVING THE C-C CHEMOKINE RECEPTOR TYPE-5 (CCR5) GENE AND USES THEREOF |
摘要 |
Disclosed herein are compositions for inactivating the human CCR5 gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the /-OnuI subfamily of LHE. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefrom are also provided. |
申请公布号 |
EP3004149(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140727480 |
申请日期 |
2014.05.28 |
申请人 |
CELLECTIS S.A.;PREGENEN INC. |
发明人 |
JARJOUR, JORDAN;ASTRAKHAN, ALEXANDER |
分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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