发明名称 |
ASSOCIATION OF N-{[(7S)-3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL]METHYL}-3-(7,8-DIMETHOXY-1,2,4,5-TETRAHYDRO-3H-3-BENZAZEPIN-3-YL)-N-METHYL-3-OXO-1-PROPANAMINE AND PERINDOPRIL |
摘要 |
Combination (I) comprises a selective and specific sinusal I f(mixed sodium ion-potassium ion inward current) current inhibitor (A) and an angiotensin converting enzyme inhibitor (B). An independent claim is included for pharmaceutical compositions comprising: ivabradine, in the form of hydrochloride or its hydrate or crystalline forms, and perindopril, in the form of salt of tert-butylamine or arginine or their hydrates or crystalline forms, alone or in combination with one or more excipient. ACTIVITY : Cardiant; Cardiovascular-Gen.; Vasotropic; Antianginal; Antiarrhythmic. MECHANISM OF ACTION : Sinusal I fcurrent inhibitor; Angiotensin converting enzyme inhibitor. |
申请公布号 |
EP2921168(B1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20150162899 |
申请日期 |
2011.06.14 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
THUILLEZ, CHRISTIAN;MULDER, PAULUS;VILAINE, JEAN-PAUL;FRATACCI, MARIE-DOMINIQUE;LEREBOURS-PIGEONNIERE, GUY;FELDMANN, LUC;ROUSSEL, JÉRÔME |
分类号 |
A61K9/20;A61K31/4045;A61K31/55;A61K45/06;A61P9/04 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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