发明名称 derivados de benzoxazol, benzimidazol, oxazolopiridina e imidazopiridina substituídos como moduladores de gama secretase.
摘要 The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
申请公布号 BRPI1016120(A2) 申请公布日期 2016.04.12
申请号 BR2010PI16120 申请日期 2010.02.15
申请人 ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. 发明人 A/C HENRICUS JACOBUS MARIA GIJSEN;DANIEL OEHLRICH;DIDIER JEAN-CLAUDE BERTHELOT;FRANÇOIS PAUL BISCHOFF;GREGOR JAMES MACDONALD;MICHEL ANNA JOZEF DE CLEYN;MICHEL SURKYN;MIRKO ZAJA;SVEN FRANCISCUS ANNA VAN BRANDT;WEI ZHUANG
分类号 C07D401/14;A61K31/4184;A61K31/423;A61K31/4439;A61K31/454;A61K31/506;A61K31/519;A61K31/5377;A61P25/00;C07D403/12;C07D403/14;C07D405/14;C07D413/12;C07D413/14;C07D471/04 主分类号 C07D401/14
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