| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula,where each Rand Ris independently selected from hydrogen, C-Calkyl, optionally substituted OH and OR, where Rrepresents C-Calkyl, or Rand Rtogether represent oxo or optionally C-Calkyl O-substituted oxime; W represents O, NR′ or CRR, where R′ represents either hydrogen, or C-Calkyl; X is either absent or represents CRR, where each R, R, Rand Rare independently selected from substituents, given for Rand R; Y and Z independently represent substituted or non-substituted nitrogen or carbon (substituents for which are given in i. 1 of the invention formula), or Y and Z together form optionally substituted pyrazolyl, imidazolyl, pyriminidyl, 1,2,4-triazolyl (substituents for which are given in i. 1 of the invention formula); Rand Rrepresent H; Rand Rrepresent H or Rand Rcan be combined with formation of C-Ccycloalkyl, optionally substituted with one or two substituents, selected from C-Calkyl and OH; Cy is selected from Calkyl(C-C)cycloalkyl, phenyl, pyridinyl and thienyl; m equals 0 or 1; Rrepresents F. the invention also relates to particular compounds, given in i. 1 of the invention formula, to pharmaceutical composition and method for treating malignant tumour.EFFECT: novel methods for Akt inhibition.19 cl, 1 dwg, 153 ex |
