发明名称 Phenalene-1-one derivatives, method for producing same and use thereof
摘要 The present disclosure relates to a compound of formula (1):; where R1 through R8, which can be identical or different from each other, each are selected from of the group comprising hydrogen and the radical —(CH2)k—X, where k is a whole number from 1 to 20 and where X is an organic radical comprising a) at least one neutral, protonizable nitrogen atom and/or b) at least one positively charged nitrogen atom, under the provision that at least 1 radical R1 through R8 is not hydrogen. The invention further relates to the production and use of said compound.
申请公布号 US9302004(B2) 申请公布日期 2016.04.05
申请号 US201214001145 申请日期 2012.02.23
申请人 TRIOPTOTEC GMBH 发明人 Bäumler Wolfgang;Felgenträger Ariane;Lehner Karin;Maisch Tim;Regensburger Johannes;Santarelli Francesco;Späth Andreas
分类号 C07D265/30;A61K41/00;A61K31/137;A61K31/14;A61K31/4425;C07C45/75;C07C217/10;C07C225/16;C07C271/16;C07C271/20;C07C279/10;C07C279/12;C07C279/24;C07D211/58;C07D213/20;C07D295/116;A61K8/41;A61K8/43;A61K8/49;A61Q11/02;A61L2/08;A61L2/10 主分类号 C07D265/30
代理机构 Ostrolenk Faber LLP 代理人 Ostrolenk Faber LLP
主权项 1. Compound of Formula (1):wherein R1 to R8, which can in each case independently of each other be the same or different, are in each case selected from the group consisting of hydrogen and the radical —(CH2)k—X, wherein k is an integer from 1 to 20, and wherein X is an organic radical which contains a) at least one neutral, protonatable nitrogen atom and/or b) at least one positively charged nitrogen atom, with the proviso that at least 1 radical R1 to R8 is —(CH2)k—X, andwherein X means a radical of Formula (2):wherein A is selected from the group consisting of an oxygen, a sulfur atom and a nitrogen atom which can be neutral or positively charged and wherein n is an integer from 1 to 8 and m is an integer from 0 to 100 and wherein B is a radical selected from the group consisting of Formula (3), Formula (4) and Formula (5):and wherein each of the radicals R(I), R(II) and R(III) independently of each other is selected from hydrogen or C1-C20 alkyl which can be straight-chained or branched and wherein the radical with Formula (5)represents a substituted or unsubstituted heterocyclic radical with 5 to 7 ring atoms which comprise at least 1 carbon atom and 1 to 4 nitrogen atoms as well as optionally 1 or 2 oxygen or sulfur atoms, wherein the heterocyclic radical is saturated or unsaturated, orwherein X is a radical selected in each case from the group consisting of Formula 10, Formula 11, Formula 12, Formula 13, Formula 14, Formula 15, Formula 16, Formula 17, Formula 18, Formula 19, Formula 20, Formula 21, Formula 22, Formula 23, Formula 24, Formula 25, Formula 26, Formula 27, Formula 28, Formula 29, Formula 30, Formula 31, Formula 32 and Formula 33:
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