Compositions comprising a radiosensitizer and an anti-cancer agent and methods of uses thereof

摘要

A combination of an anti-cancer agent and a metal radiosensitizer potentiates the radiotherapy of cancer. Said anti-cancer agent is preferably cisplatin while the metal radiosensitizer is preferably gold nanoparticles. Both the anti-cancer agent and the metal radiosensitizer bind to DNA and potentiate the radiotherapy of cancer by synergistically increases the amount of double strand breaks induced by the radiation. The anti-cancer agent and the metal radiosensitizer may be encapsulated in liposomes.

主权项

1. A method of potentiating ionizing radiotherapy which produces low energy electrons comprising:
(a) administering to a subject in need thereof an effective amount of a composition comprising (i) an anti-cancer agent comprising platinum which binds to DNA and (ii) gold nanoparticles consisting of gold, and optionally, a stabilizer; and (b) administering to the subject ionizing radiotherapy which produces low energy electrons, wherein (a) occurs prior to (b); and whereby (a) potentiates the ionizing radiotherapy of (b).