COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF TUBERCULOSIS

摘要

The present invention relates to compounds which have a higher binding affinity than the natural substrate or natural ligand of three protein targets involved in Mycobacterium tuberculosis metabolic pathways. The protein targets being cytidylate kinase (cmk), nicotinate mononucleotide adenylyltransferase (nadD) and ATP synthase epsilon chain (AtpC). The invention further relates to pharmaceutical compositions containing the compounds, uses of the pharmaceutical compositions and methods of treatment of tuberculosis.