发明名称 |
BORONATE-MEDIATED DELIVERY OF MOLECULES INTO CELLS |
摘要 |
Cargo molecules carrying one or more phenylboronate moieties useful for cellular uptake of the cargo molecules. Phenylboronate can be ligated, crosslinked or otherwise bonded to the cargo molecules. Cargo molecules include peptides and proteins. The phenylboronate groups are optionally conjugated to the cargo molecule via linking moieties that can be selectively cleaved, such cleavable linkers can allow the phenylboronate groups to be removed from the cargo molecule after the boronated cargo molecule is introduced into the cell. The invention includes certain phenylboronates which are boronation reagents, certain boronated oligopeptides and certain boronated peptides and proteins. The invention also includes kits for enhancing cellular uptake of cargo molecules by boronation with one or more phenylboronates or boronated oligopeptides. |
申请公布号 |
US2016083706(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
US201514957040 |
申请日期 |
2015.12.02 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
RAINES Ronald T.;Ellis Gregory;Palte Michael |
分类号 |
C12N9/36;C12N9/22 |
主分类号 |
C12N9/36 |
代理机构 |
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代理人 |
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主权项 |
1. A cargo molecule to which one or more phenylboronate moieties are covalently bound. |
地址 |
Madison WI US |