发明名称 |
COMBINATIONS AND DOSING REGIMES TO TREAT RB-POSITIVE TUMORS |
摘要 |
This invention directed to methods for treating select RB-positive cancers and other Rb- positive abnormal cellular proliferative disorders using CDK4/6 inhibitors in specific dosing and combination or alternation regimes. In one aspect, treatments of select RB-positive cancers are disclosed using specific CDK4/6 inhibitors in combination or alternation with another chemotherapeutic, for example, an additional kinase inhibitor, PD-1 inhibitor, or BCL-2 inhibitor, or combination thereof. |
申请公布号 |
WO2016040858(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
WO2015US49777 |
申请日期 |
2015.09.11 |
申请人 |
G1 THERAPEUTICS, INC. |
发明人 |
STRUM, JAY, COPELAND;BISI, JOHN, EMERSON;ROBERTS, PATRICK, JOSEPH;SORRENTINO, JESSICA, ANN;STORRIE-WHITE, HANNAH |
分类号 |
A61K31/519 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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