Compositions and methods related to TIM-3, a TH1-specific cell surface molecule

摘要

P:OPERMKR/SPEC2003303082-div.doc-29/05/2009 The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods 5 useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Thi cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.