Insulin pump

摘要

The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimizing the gain factor based on the historical data in relation to the patient.

主权项

1. An apparatus for controlling an insulin pump, the apparatus comprising:
a user input for receiving a first gain factor, the first gain factor having been calculated based on historical data in relation to a patient; a measurement input for receiving data representative of a measured blood glucose level for the patient; and processing logic configured to: apply the measured blood glucose level to an insulin secretion computational model to predict an insulin output level; apply the first gain factor to the predicted insulin output level to determine a patient insulin deficiency level; and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level; wherein the processing logic is configured to apply the first gain factor to the predicted insulin output level for a first period of time after ingestion of a meal by the patient; wherein the first gain factor is arranged to be tuned to the patient by minimizing a predicted insulin output level cost function based on historical data of the patient; and wherein the user input receives a second and third gain factors, the second and third gain factors having been calculated based on the historical data in relation to the patient, and the processing logic being configured to: apply the second gain factor to the predicted insulin output level when the blood glucose level for the patient is equal to or above a predetermined glucose threshold; and apply the third gain factor to the predicted insulin output level when the first period of time expires and when the blood glucose level for the patient is below the predetermined glucose threshold.