Diagnostic method for Alzheimer's disease

摘要

The present invention provides an ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient, the method comprising the steps of determining the level of expression of at least four platelet proteins in a platelet sample from the patient selected from monoamine oxidase-B, coagulation factor Xllla, total tropomyosin (a and 13), WD-repeat protein 1 and apolipoprotein E4; and comparing the result of (i) to a control value, wherein a result higher than the control value is indicative of Alzheimer's disease. Preferably, the method of the invention further comprises determining the level of expression of wild-type GSTO-1 or mutant GSTO-1.

主权项

1. An ex vivo method for detecting platelet proteins, comprising
detecting at least four platelet proteins in a platelet sample from the patient selected from monoamine oxidase-B, coagulation factor XIIIa, total tropomyosin (α and β), WD-repeat protein 1 and apolipoprotein E4 (ApoE4), wherein said detecting comprises contacting a biochip array with the platelet sample, wherein the biochip array comprises a solid support having antibodies of the platelet proteins immobilized thereon.