| 发明名称 |
RECOMBINANT NEURAMINIDASE AND USES THEREOF |
| 摘要 |
A recombinant neuraminidase based on amino acid sequence (SEQ ID NO: 1) of wild-type pH1N1-NA (A/Texas/05/2009) influenza virus is provided. The recombinant neuraminidase of the present invention has an ectodomain with an amino acid sequence essentially identical to SEQ ID NO: 1 and replaced at specific positions 149, 344, 365 and 366 residue(s) with corresponding amino acids of other influenza viruses. The recombinant neuraminidase may incur cross-protective immunity and be used as universal influenza vaccine. |
| 申请公布号 |
US2016067328(A1) |
申请公布日期 |
2016.03.10 |
| 申请号 |
US201514685286 |
申请日期 |
2015.04.13 |
| 申请人 |
National Tsing Hua Univerisity |
发明人 |
WU Suh-Chin;LIU Wen-Chun;LIN Chia-Ying |
| 分类号 |
A61K39/145;C12N7/00;C12N9/24 |
主分类号 |
A61K39/145 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant neuraminidase, comprising an ectodomain provided with an amino acid sequence essentially identical to SEQ ID NO: 1, wherein the amino acid sequence comprises one of the following amino acids:
(i) V replacing I at position 149; (ii) Y or H replacing N at position 344; and (iii) TA, TN or ED replacing IS at positions 365 and 366. |
| 地址 |
Hsinchu TW |
