| 发明名称 |
Controlled-Release Melatonin Compositions and Related Methods |
| 摘要 |
A method of treating a human subject in need of melatonin therapy includes administering to a human subject a compressed tablet comprising melatonin, citric acid, and a cellulosic polymer. The melatonin, citric acid, and cellulosic polymer combine after ingestion to form an acidic hydrogel that dissolves the melatonin and is effective to provide a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep while in the human subject's gastrointestinal tract. |
| 申请公布号 |
US2016067186(A1) |
申请公布日期 |
2016.03.10 |
| 申请号 |
US201514942299 |
申请日期 |
2015.11.16 |
| 申请人 |
Zx Pharma, LLC |
发明人 |
Shah Syed M.;Hassan Daniel |
| 分类号 |
A61K9/20;A61K31/4045 |
主分类号 |
A61K9/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a human subject in need of melatonin therapy, the method comprising administering to a human subject a compressed tablet comprising an effective amount of melatonin, citric acid, and a cellulosic polymer that combine after ingestion to form an acidic hydrogel that dissolves the melatonin and is effective to provide a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep while in said human subject's gastrointestinal tract. |
| 地址 |
Boca Raton FL US |
