Human <i>Streptococcus pneumoniae </i>antibodies and uses therefor

摘要

The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of Streptococcus pneumoniae infections. In particular, these antibodies may kill Streptococcus pneumoniae or limit the replication of Streptococcus pneumoniae. Also disclosed are improved methods for producing such monoclonal antibodies.

主权项

1. A method of treating a Streptococcus pneumoniae infection in a subject comprising administering to said subject at least one antibody that binds selectively to Streptococcus pneumonia, wherein said antibody comprise
i) a heavy chain [CDR] selected from the group consisting of the nucleotide sequence set forth in SEQ ID NOS: 127, 122, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 161, 162, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, and 238; and ii) a light chain [CDR] selected from the group consisting of the nucleotide sequence set forth SEQ ID NOS: 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, and 252.