Methods of synthesis and purification by use of a solid support

摘要

Disclosed herein are novel methods of using polymeric adsorbent resin for chemical synthesis and the purification of product therefrom. Also disclosed herein is a novel method of using silica gel for the combination of chemical reaction and chromatography into a single step. The methods disclosed herein increase the efficiency of chemical synthesis processes. Accordingly, the utility of the methods disclosed herein includes the ability to automate chemical synthesis and purification of the resulting products.

主权项

1. A method of purifying a product, the method comprising:
contacting a resin with a mixture comprising an aqueous solution, the product, and an organic solvent, wherein the organic solvent enters the pores of the resin and some of the product is dissolved in the organic solvent; adding a water-based solution to remove one or more unwanted by-products; optionally, adding water to remove or dilute the water-based solution; and adding a dislodging solvent to dislodge the product from the resin, where (a) the mixture is a two phase mixture, (b) the resin is a high internal phase emulsion polymeric (polyHIPE) resin which is prepared from polymerization of an emulsion of an aqueous phase and an oil phase comprising divinylbenzene and sorbitan monooleate, and (c) the resin has a pore volume of more than 1.8 ml/g.