Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof

摘要

The invention is directed to a compound according to formula (I). The compounds of formula (I) include prodrugs, pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier and to methods for treating diabetes by administering such a pharmaceutical composition alone or in combination with other therapeutic agents. The invention is also directed to inhibitors of fructose-1,6-bisphosphatase.;

主权项

1. A compound according to formula (I)wherein,
A is oxygen, CH2, sulfur, NH or, NCH3; R1, R2, and R3 are each independently selected from the group consisting of hydrogen, halogen, branched or unbranched, substituted or unsubstituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, alkoxy, aryloxy, aryl, alkylaryl, alkoxyaryl, epoxide, —COOH, —CN, —CX3, —C(O)R6, —C(O)N(R6)2, —C═C═C(R6)2, —OH, —OAc, —OC(O)R6, —SO3, —S(O)2R6, —S(R6), —SAc, —NHC(O)Ar, —NHCH2Ar, —N(R6)2, —N═N(R6), —SiH3, —P(O)(X)2, —P(O)(OR6)2, —P(R6)2, —OPO3, where X is a halogen, Ac is acetyl, and Ar is an aryl group; R4 and R5 are each independently selected from propyl, allyl and propargyl; each R6 is independently H or C1-C4 alkyl; n is an integer from 0-5; and pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof.