The present invention provides an engineered clostridial toxin comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pI) of the engineered clostridial toxin to a value that is at least 0.2 pI units higher than the pI of an otherwise identical clostridial toxin lacking said at least one amino acid modification. Also provided are corresponding uses of the engineered clostridial toxin in therapy.
申请公布号
SG11201600150U(A)
申请公布日期
2016.02.26
申请号
SG11201600150U
申请日期
2014.07.09
申请人
IPSEN BIOINNOVATION LIMITED
发明人
ANDERSON, DINA BRADY;HACKETT, GAVIN STEPHEN;LIU, SAI MAN